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Ülkemizde ve dünyada yaşlı nüfus büyük bir hızla artmaya devam ediyor. Günümüzde tüm dünyada 44 milyon bunama hastası var. Türkiye İstatistik Kurumu verilerine göre 2023 yılında ülkemizin 65 yaş üstü yaşlı nüfus oranının %10’un üzerine çıkacağı ve bunama hastalıklarının sıklığının büyük bir hızla artmaya devam edeceği tahmin ediliyor. Bu artış trendi sürerse 2050 yılında hasta sayısının tüm dünyada 135 milyona çıkması bekleniyor. Her yıl 21 Eylül günü Dünya Alzheimer Günü olarak kabul ediliyor.

Dünya Alzheimer Günü nedeniyle 19 Eylül’de Türkiye Alzheimer Derneği bir toplantı düzenledi. Dünya Alzheimer Günü basın toplantısında Türkiye Alzheimer Derneği Başkanı Prof. Dr. Işın Baral Kulaksızoğlu, Türkiye ve Almanya Alzheimer Derneklerinin, Aizheimer’s Disease International (ADI) tarafından 2014’te kardeş dernek ilan edildiğini bildirerek bu işbirliği hakkında bilgi verdi. Toplantıda Alzheimer’da yeni bulunan proteinler, yaşam tarzının Alzheimer hastalığı üzerine etkisi, gelişmiş ülkelerde Alzheimer’in azalmasının olası sebepleri gibi yeni bilgilerin yanı sıra Türkiye Alzheimer Derneğinin faaliyetleri de aktarıldı.

Türkiye Alzheimer Derneği merkezinde gerçekleştirilen toplantıda Türkiye’nin de dahil olduğu 84 ülkeden üyesi olan Dünya Alzheimer Örgütü’nün (ADI) Dünya Alzheimer 2014 Raporu açıklandı.

Prof. Dr. Işın Baral Kulaksızoğlu, bu salgın denebilecek durum karşısında özellikle yaşlı nüfusa sahip gelişmiş ülkelerin alarma geçerek eylem planları oluşturduklarını ifade etti. 2012 yılında oluşturulan ve G8 zirvesinde de taslak olarak kabul edilen ABD Ulusal Alzheimer Planına göre 2025 yılında Alzheimer hastalığının (AH) önlenmesi ve etkili bir şekilde tedavisi hedefleniyor. Özellikle hastalık açısından risk yaratan durumların azaltılması ve koruyucu olduğu bilinen faktörlerin desteklenmesinin bu salgını azaltabilmesi bekleniyor.

 

Sıklık azalsa da yaşlı nüfus artıyor

Başkan Yardımcısı Prof. Dr. Haşmet Hanağası tüm dünyada Alzheimer ve bunama hastalarının sayısı artsa da gelişmiş ülkelerden (ABD, Almanya, Hollanda, İsveç ve İngiltere) gelen umut verici yeni verilere bakıldığında yaşlılarda bunama hastalığının görülme sıklığında geçmişe oranla azalma olduğunu ifade etti. Prof. Hanağası “Tıp dünyasında oldukça ünlü olan Framingham çalışmasında 30 yıl önceki yaşlılara göre şimdiki yaşlılar arasında yeni bunama hastası görülme sıklığında %44’e varan azalma mevcuttur. Araştırmacılar bu düşüşü eğitim düzeyinin artması, daha fazla zihinsel işlev gerektiren iş kollarının artması, hipertansiyon ve hiperkolesterolemi gibi damarsal risk faktörlerinin daha yaygın olarak kontrol altına alınması, sigara tüketiminin azalmasına bağlamaktadır. Günümüzde artan şeker hastalığı ile daha etkin mücadele ile bu oranın daha da azalması mümkün olabilir. Gelişmekte olan ve gelişmemiş ülkelerdeki hastalık oranlarının düştüğüne dair henüz bir veri yoktur” şeklinde konuştu.

 

Alzheimer hastalığından korunma genç yaşlarda başlıyor

Yönetim Kurulu Üyesi Prof. Dr. Haşmet Hanağası Alzheimer hastalığından korunma hakkında şunları söyledi: “Alzheimer hastalığında genç yaştan itibaren risk faktörleri ve koruyucu faktörlerin birbirleri ile yarıştığı ve orta yaşlarda risk faktörlerinin azaltılarak fiziksel ve zihinsel aktivitelerin arttırılmasının yararlı olduğu bilinmektedir. Bu yıl Dünya Alzheimer Kongresinde sunulan yeni bulgulardan birisi de orta yaşlarda daha fazla kart oyunları, dama oynayanlar ve bulmaca çözenlerin beyinlerinin daha hacimli olduğu ve bu kişilerin zihinsel yetilerinin bu aktiviteleri yapmayanlara göre daha iyi bulunduğu şeklindedir.”

 

Alzheimer’den korunmak için her yaşta aktif olmak gerek

“Orta yaşlarda koruyucu faktörlerin etkisi daha aşikar iken, risk altındaki yaşlılarda koruyucu faktörlerin ve risk faktörlerinin düzenlenmesinin yararlı etkisinin olup olmadığı bilinmiyordu. Bu soruya cevap olarak 2 yıl boyunca İskandinav ülkelerinde 1260 yaşlı kişi (60-77 yaş arası) ile yapılan bir çalışma, yaşlı kişilerde beslenme önlemleri, zihinsel egzersiz, sosyal aktiviteler ve kalp sağlığı önlemleri ile yaşlılardaki zihinsel gerilemenin azaltılabileceği ve bunamanın kısmen önlenebileceğini göstermiştir. Böylelikle düzenli beslenme, daha sosyal bir hayat ve zihinsel egzersizlerin hastalığa karşı etkili yöntemler olduğu bilimsel olarak ispatlanmıştır ve yaşlılar bu konuda yönlendirilmeli ve sağlık politikaları bu bilgiler ışığında oluşturulmalıdır.”

 

Ancak 90 yaşa gelirseniz hipertansiyon zararlı bir bulgu değil

Prof. Dr. Haşmet Hanağası, farklı yaşlardaki hakkında sorulara “Bu sene ortaya çıkan oldukça ilginç bulgulardan birisi de 90 yaş ve üstü bireylerde tansiyon yüksekliğinin koruyucu bir faktör olduğunun saptanmasıdır. Oysa orta yaş ve 90 yaş altındaki kişilerde tansiyon yüksekliği Alzheimer hastalığı açısından ciddi bir risk faktörüdür. Bu ilginç bulgu her yaşta risk faktörlerinin değiştiğini ve dinamik olduğunu göstermektedir. Bu dinamik duruma bir diğer örnek de Mayo Clinic tarafından yapılan çalışmalarda orta yaşlarda (50-65 yaş) yapılan fiziksel aktivitenin Alzheimer hastalığı açısından koruyucu olmasına karşın 70 yaş ve üstü kişilerde fiziksel aktivitenin koruyuculuğu konusunda bazı şüphelerin olmasıdır. Güncel bilgiler ışığında orta yaşlarda tempolu yürüyüşler gibi fiziksel aktiviteler özendirilmelidir” diye cevap verdi.

 

Alzheimer hastalığının erken tanısı için araştırmalar hızla sürüyor: Yöntemler deneysel de olsa umut vaat ediyor

Alzheimer tanısının nasıl konduğuna dair bilgi veren Doç. Dr. Başar Bilgiç “Hastalığı tanımak günümüzde artık daha kolay hale geldi” diyerek tanı yöntemlerini sıraladı: “Gerek pozitron emisyon tomografisi gerekse de beyin omurilik sıvı analizi ile henüz hastalığa ait şikayetler başlamadan tanı konulabilmekte ve risk belirlenebilmektedir. Beyinde biriken iki protein olan amiloid ve tau proteinleri artık görüntüleme yöntemleri ile gösterilebilir hale gelmiştir ama bu yöntemlerin yaygınlaşması teknik sorunlardan dolayı oldukça zordur ve bu yöntemler pahalı yöntemlerdir. Bu amaçla çok daha kolay uygulanabilir biyolojik belirteçlere ihtiyaç vardır. Göz birebir beyinle bağlantılı bir organ olduğundan beyindeki değişimler sıklıkla kendini gözde de göstermektedir. Bu hastalıkta beyinde biriken beta-amiloid isimli maddenin son yıllarda gözde retina katmanı ve lens içinde de biriktiği saptanmıştır ve basit bir şekilde gözde bu maddenin birikimi gösterilerek hastalığın tanısının yapılabileceği öne sürülmüştür. Gözdeki bu birikim zamanla artış göstermektedir. Bu yöntem rüştünü daha fazla ispatladığında hem tanı hem de takip amaçlı olarak kullanılabilir. Benzer şekilde Alzheimer hastalarında hastalıktan önce koku alma bozukluğu belirmektedir ve koku alma yeteneği beyin hacmi ile birebir ilişki göstermektedir ve hastalık ile beraber zihinsel yıkıma paralel şekilde koku alma yeteneği de azalmaktadır. Böylelikle koku testleri ile riskli bireylerin belirlenebileceği ve hastalık takibinde kullanılabileceği öne sürülmüştür”.

 

Alzheimer hastalığında yeni bir protein bulundu

Yönetim Kurulu Üyesi Doç. Dr. Başar Bilgiç “Alzheimer hastalığında beyinde biriken iki önemli protein amiloid ve tau proteinleridir. Bu yıl ortaya konan önemli bilgilerden birisi de hastalarda bu iki protein dışında bir üçüncü protein olan TDP-43 isimli proteinin beyinde biriktiği ve zihinsel fonksiyonlar ve beyin hacmi ile ilişkili olduğudur. Tedavi girişimlerinde bu proteinin de beyinden temizlenmesi yeni ve etkili bir strateji olabilir” dedi.

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    โดยสามารถเลือกลงฝั่งไหนก็ได้ โดยวางเดิมพันฝั่งนั้นแล้วรอคอยเปิดไพ่เพื่อที่จะได้ดูว่าได้แต้มเท่าใด และก็คนใดมีแต้มมากยิ่งกว่ากัน ซึ่งกติกาการเล่นจะมีลักษณะคล้ายกับไพ่ป๊อกกระเด้งบ้านพวกเราที่ตัดสินโดยใช้วิธีนับแต้มสูง ฝั่งไหนมีแต้งสูงสุดฝั่งนั้นชนะ เว็บไซต์พนันของพวกเรา มีpartnerรวมไว้ให้แก่คุณเลือกเล่นได้ตามสบาย สามารถเลือกโต๊ะได้แบบไม่มีข้อจำกัดโดยแต่ละโต๊ะก็จะมีต้นแบบการเดินเกมต่างๆนาๆ ด้วยความที่ไพ่บาคาร่ามีข้อตกลงที่ไม่สลับซับซ้อนเราทำความเข้าใจได้ง่าย ไม่ว่าท่านจะไม่เคยเล่นมาก่อนไหมมีพื้นฐานการเล่นไพ่เลยก็สามารถเล่นได้ บาคาร่านั้นมีแบบอย่างให้พวกเราเลือกลงพนันที่หลากหลาย จึงทำให้นักการพนันทั้งหลายไม่เคยทราบสึกระอา ไม่ซ้ำจากจำเจ ลุ้นได้หลายแบบ และท่านจะได้เล่นผ่านบริษัทแม่โดยตรงเพราะฉะนั้นท่านสามารถให้ความวางใจกับเว็บของพวกเราได้เลยครับผม ยืนยันได้ว่าไม่มีปัญหาตามมาอย่างไม่ต้องสงสัย แค่เพียงลงทะเบียนสมัครสมาชิกกับพวกเราก็จะได้รับ user แล้วก็ password มีเพียงแค่ยูสเดียวก็สามารถเล่นได้อีกทั้งคาสิโนโดยไม่ต้องสมัครใหม่เพื่อจะเล่นได้หลายๆเกมให้ยุ่งยาก เล่นได้ครบจบที่ยูสเดียว ในขณะนี้ บาคาร่าออนไลน์เป็นที่นิยมกันมากมาย ทุกคนทุกเพศทุกวัยต่างก็กล่าวถึงแล้วก็อยากทดลองเล่น
    ณ เดี๋ยวนี้กล่าวได้ว่าไม่มีผู้ใดไม่ทราบบาคาร่า หลายท่านต่างก็สนใจเกี่ยวกับการเล่นบาคาร่ามากยิ่งกว่าการพนันชนิดอื่นๆเนื่องจากไม่ซับซ้อน เล่นง่ายได้เงินเร็ว ไม่ซ้ำซาก หลายท่านเข้ามาเล่นแล้วทำกำไรได้ในระยะยาว บางบุคคลเข้ามาเล่นแค่ชั่วครั้งชั่วคราวแล้วได้ผลทดแทน มีกำไรแล้วหยุดเล่นก็จัดว่าคุ้มในระดับนึง การเล่นไพ่จำพวกนี้นั้นผลตอบแทนเป็นผลกำไรจะได้มากหรือได้น้อยก็ขึ้นอยู่กับจังหวะการออกไพ่ในแต่ละรอบ ดวง ความชำนาญรวมทั้งเคล็ดวิธีที่ดี ประสบการณ์ในการเล่น การมองเกมออก ก็สามารถได้กำไรจากที่ตรงนี้ได้ไม่ยากแล้ว การเล่นไพ่ประเภทนี้ก็เลยตอบโจทย์นักการพนันหลายท่าน และกลายเป็นที่ชื่นชอบอยู่ในใจของคนอีกหลายคน
    การพนันจะมีรายละเอียด ศัพท์ ข้อตกลงต่างๆชี้แจงให้เข้าใจง่ายๆได้ดังนี้ คำศัพท์โดยประมาณที่ใช่ในเกมที่ท่านควรทราบเป็นเบสิกสำหรับในการเล่นหมายถึงPlayer หรือผู้เล่น ,
    Banker หรือ เจ้ามือ , TIE หรือ เสมอ , Bonus หรือที่เราเรียกกันว่าโบนัสนั่นเอง , player pair หรือ banker pair เป็นการลงพนันแบบไพ่ออกแต้มมาคู่กัน นอกเหนือจากนั้นยังมีข้อตกลงการเรียกไพ่ใบที่ 3 ถ้าท่านเลือกลงเดิมพันฝั่งผู้เล่น
    (player) แล้วได้ไพ่สองใบแรกออกแต้มมาเป็น 0-5 แต้ม ท่านจะต้องเรียกไพ่ใบที่ 3 อัตโนมัติ ถ้าเกิดไพ่ออกมาได้ 5-6 แต้ม ท่านจำต้องคอยฝั่งตรงข้ามเป็นฝั่งเจ้ามือ (banker)
    ว่าได้แต้มเท่าไร ถ้าหากฝั่งเจ้ามือได้ 8-9 แต้มก็จะจบเกมโดยทันที เนื่องจากว่าเป็นแต้มที่สูงที่สุดของไพ่แล้ว และก็อีกอย่างที่ท่านจำต้องรู้เกี่ยวกับกติกาก็คือขั้นตอนการนับคะแนน หรือการออกแต้มของไพ่ ซึ่งถ้าไพ่ออกมาเป็น A = 1แต้ม , ถ้าหากได้ไพ่ J
    Q K 10 = 0 แต้ม , ถ้าหากออกไพ่มา 2-9 =
    2-9 แต้ม แม้ได้ไพ่มาก็สามารถนับแต้มได้ตามไพ่ได้เลยแนวทางการเลือกเดิมพัน เราสามารถเลือกลงพนันได้หลายแบบอย่าง ดังต่อไปนี้-ฝั่งผู้เล่น
    หากพวกเราเลือกลงทุนฝั่งเจ้ามือ (player) แล้วแต้มออกมาสูงขึ้นยิ่งกว่าอีกฝั่งท่านจะชนะ โดยมีอัตราผลตอบแทนคือ 1 : 1 หากเราเลือกลงทุนฝั่งเจ้ามือ (banker) แล้วไพ่ออกมาแต้มสูงหรือมากยิ่งกว่าอีกฝั่งจะมีอัตราผลตอบแทนเป็น 1 : 0.95 -การเลือกลงทุนแบบเสมอหรือTIEนั้น ถ้าเกิดไพ่ส่งผลออกมาเสมอกันระหว่างผู้เล่น(player)
    กับเจ้ามือ(banker) ยกตัวอย่างเช่น 4-4 5-5 8-8 2-2 แค่เพียงไพ่ออกแต้มมาเท่ากัน ท่านก็จะเห็นผลทดแทนมากยิ่งกว่าการลงเดิมพันแบบปกติถึง 8 เท่า -การลงพนันอีกแบบอย่างนึงเป็น การเลือกพนันแบบโบนัส(Bonus) เป็นการลงพนันโดยต้องลุ้นให้ไพ่ที่ออกมานั้นห่างกันมากยิ่งกว่า 4 แต้ม ตัวอย่างเช่น
    ถ้าท่านเลือกลงพนันฝั่งเจ้ามือ(banker) ไพ่ฝั่งผู้เล่นออกแต้มมา 2 แต้ม ไพ่ฝั่งเจ้ามือจำต้องออกแต้มมากกว่าหรือพอๆกับ 6 แต้มเท่านั้น
    ก็เลยจะชนะและก็ได้รับโบนัสทันที และก็ถ้าหากท่านเลือกลงพนันฝั่งใดฝั่งนึงแล้วได้ไพ่มากยิ่งกว่าอีกฝั่ง 8 แต้มขึ้นไปท่านจะได้ผลตอบแทนไปเลย 30 เท่า -รวมทั้งการลงเดิมพันแบบในที่สุด
    คือการลงพนันแบบไพ่คู่ ถ้าท่านเลือกลงไพ่คู่ฝั่งเจ้ามือ
    (banker pair) ไพ่2ใบแรกจำต้องออกมาเป็นเลขที่เช่นเดียวกันทั้ง2ใบ ได้แก่ 1-1 2-2 อย่างเดียวกันถ้าท่านเลือกลงเดิมพันไพ่คู่ฝั่งผู้เล่น
    (player pair) ถ้าไพ่ 2 ใบแรกออกมาแต้มเช่นเดียวกันท่านก็จะได้รับผลตอบแทนมากยิ่งกว่าธรรมดาไปเลย 11
    เท่าสำหรับต้นแบบเกมก็จะมีลักษณะแบบที่กล่าวไปข้างต้นวนๆไปอย่างนี้ตลอดทั้งเกม และผลตอบแทนจะต่างกันออกไปในแต่ละโต๊ะ ท่านสามารถเลือกลงเดิมพันตามทักษะได้ตามอยาก
    รวมทั้งสามารถเปลี่ยนแปลงกรรมวิธีการลงเดิมพันตามวิธีการของแม้กระนั้นคนเพื่อเพิ่มช่องทางสำหรับการทำกำไรได้เลย

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